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Topical Treatments for Impotence
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Injection and topical cream treatments for Impotence
employ various agents that have properties that help
achieve erection. The standard agents to treat Impotence
include Alprostadil, Phentolamine and Papaverine.

An Impotence study examined a progressive injection
protocol that starts with a less complex and expensive
combination of treatment drugs and also advanced to
more complex and costly regimens until positive results
are achieved. The Impotence treatment drugs used in the
studies protocol were Papaverine, Phentolamine,
Prostaglandin E1 and Atropine Sulfate. The logic behind
the protocol is to find the least costly and complex therapy
that works for the patient. Positive response rates were as
high as 97.6%. Although any or all of these agents are very
effective, injections or other invasive methods of
administration are awkward and uncomfortable. Topical
forms of some of these agents are showing promise.

Topical Treatments for Impotence

Alprostadil is derived from a natural substance,
prostaglandin E1, and acts by opening blood vessels. It is
an effective alternative Impotence treatment for some men.
It can be administered in three ways. The first is by
injection it into the erectile tissue of the penis. The second
is by a device that administers the Impotence drug through
the urethra. And lastly by using a topical cream such as
Topiglan or Alprox-TD. These topical Impotence  
treatments are an easier and effective source of treatment.

Regardless of how it is administered, the drug Alprostadil
works in many men with a wide range of medical
disorders related to Impotence. These other medical
disorders including the following: diabetes, surgery and
physical Injury. In spite of its general success, self-injection
therapy has a high dropout rate and is less likely to be
used now that oral treatments are available. The
Impotence drug should not be injected more than three
times a week or more than once within a 24 hour period.

Side Effects of Most Alprostadil Impotence Methods

Alprostadil is not an appropriate choice for men with
severe circulatory or nerve damage, men with bleeding
abnormalities, men with penile implants or are taking
drugs that thin the blood, such as heparin or warfarin.

Certain side effects are common to all methods of
administration, although they may differ in severity
depending on how the Impotence treatment drug is
administered. In one study, half of the men with injected
Alprostadil experienced some burning and pain at the
injection site. Side effects with injections may include
scarring of the penis. Other symptoms may include
dizziness, light-headedness, and fainting due to a sudden
drop in blood pressure. If these symptoms occur, the man
should lie down immediately with his legs raised.  As a
possibility with any method, but less chance with the
MUSE system than with injections, a prolonged erection
may happen known as priapism. If this occurs, applying
ice for ten-minute periods to the inner thigh may help
reduce blood flow. Erections that last for four hours or
longer requires emergency care.

There is also a possibility of side effects on female
partners. Women partners may experience vaginal burning
or itching. The drug may have toxic effects if it reaches the
fetus in pregnant women, so men should not use
Alprostadil for intercourse with pregnant women without
the use of a condom or other barrier contraceptive device.

Injected Alprostadil such as Caverject or Edex employs a
very small needle that is injected into the erectile tissue of
the penis. About 80% of men report the pain of
administering the injection as being very mild. Edex which
is a newer and less expensive form of injected Alprostadil.
In one study of 894 patients, Edex injections achieved
erections in 95% of attempts after 12 months. There is
some evidence that the agent may have long-term benefits
on smooth muscles and some men report some return to
spontaneous erections after long-term use.

Topical Treatments for Impotence

Alprostadil is being developed as a topical Impotence
cream or gel as additional treatment options for
Impotence. These topical treatment creams include the
names Topiglan and Alprox-TD. The topical treatment
cream for Impotence is applied to the tip of penis 15
minutes before intercourse. Studies are reporting an
efficacy rate of 40% to 75% with no significant side
effects. The most common side effect reported is a
burning sensation at the application site. The
consequences to the female partner are not known and
haven’t been studied as of yet.

The topical treatment cream for Impotence acts locally on
penile tissue. If the topical application of cream precedes
sexual intercourse, the release of neurotransmitters
prompted by erotic stimulation will enhance further the
action of the agents and result in a better erection. The
greatest effect was seen in psychogenic Impotence with or
without a neurogenic disorder and the lowest in vascular
Impotence. This may be because the agents in the active
topical treatment cream are primarily vasodilators and
penile vasculature is healthy in psychogenic Impotence but
compromised in vascular dysfunction. During laboratory
testing the active topical treatment Impotence cream
significantly increased penile arterial flow and induced
tumescence in 66% of patients. Even though more studies
are needed, topical treatments for Impotence with a cream
containing aminophylline, isosorbide dinitrate, and co-
dergocrine mesylate might be considered before the
intracavernous injection of drugs.